Research Lab Tech I

At the Harvey Cushing Neuro-Oncology Laboratories (HCNL) at Brigham and Women's Hospital, our research is focused on developmental immunotherapy with tumor-permissive oncolytic viruses and tumor immune mechanisms governing high immune tolerance and resistance in brains with tumors. We use advanced DNA manipulation and animal models in conjunction with the latest molecular and immunological tools in our investigation of brain tumors and immunity.

We are looking for an energetic and highly organized Research Assistant interested in a variety of animal experiments, cell culture and tissue processing, molecular biology, and essential molecular biological experiments. The position will involve assisting postdoctoral fellows and senior scientists on animal handling aspects of brain tumors and related research. The HCNL offers vast opportunities for personal development and education for those who are willing to participate in our research goals.

We are looking for a candidate who can make at least 1-year commitment to the position to contribute technically to newly funded NIH grant studies. A long-term contribution of more than 1 year is preferable.

Potential candidates should hold at least a Bachelor's degree in biology, veterinary, neuroscience, immunology, or a related field; and experience working in research labs or animal facilities that handle mice.

We consider candidates who are willing to work with small animals performing the following techniques: mouse handling, intraperitoneal injection, tail-vein injection, perfusion, tissue dissection, blood sampling, colony and breeder maintenance, and genotyping. Past experiences in stereotactic injection, brain dissection, magnetic resonance imaging (MRI) and bioluminescent imaging (BLI) and other imaging techniques of small animal, microtome/cryostat tissue sectioning or immunological assay such as PBMC isolation, FACS staining, and ELISA/ELISpot have the great advantage to consider but is not required. Good laboratory practices, well organized planning and performing lab work, and maintaining good lab records and notebooks are necessary.

The candidate should be able to communicate with lab members clearly and in a professional manner. Strong motivation for curiosity-driven research and constant improvement in technologies, along with excellent communication (oral and written) skills and the ability to work as part of a team, is required.

As a member of the research staff, your duties and responsibilities will include:

* Working with graduate students, postdoctoral fellows, and other staff members on research projects

* Maintain and organize collected DATA and good lab records in online system

* Work with experimental animals and cultured cells

*Perform general lab maintenance.