Scientist, Capsid Engineering

At Roche you can show up as yourself, embraced for the unique qualities you bring. Our culture encourages personal expression, open dialogue, and genuine connections, where you are valued, accepted and respected for who you are, allowing you to thrive both personally and professionally. This is how we aim to prevent, stop and cure diseases and ensure everyone has access to healthcare today and for generations to come. Join Roche, where every voice matters.

A healthier future. It's what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That's what makes us Roche.

The Scientist, Capsid Engineering is a key member of the Discovery Research Team and participates in the development of Spark's gene delivery platforms. You will be critical for the development of novel AAV capsids with enhanced properties, in particular the ability to transduce specific cell types. The discovery of such capsids will greatly facilitate the translation from in vitro through in vivo proof of concept and ultimately the clinic.

The Opportunity:

• Developing and implementing the production of rationally designed AAV variants and improved AAV capsid libraries.

• Supporting approaches that allow the isolation of AAV capsid variants that transduce specific cell types in both rodents and NHPs.

• Actively collaborate with the NGS and machine learning groups to further enhance the power of using directed evolution to isolate AAVs with tailored properties.

• Collaborating with other Discovery and Gene Therapy scientists to design and conduct in vitro studies in preclinical animal models of genetic diseases.

• Supporting joint programs and collaborations with external parties.

• Writing study reports, manuscripts and present results at appropriate scientific meetings.

Who You Are:

• PhD in a biological discipline and 3-5 years of related experience.

• Hands-on research experience with high complexity library preparations.

• Familiarity with NGS and bioinformatics is required.

• Experience in general and advanced lab techniques such as plasmid design and construction, molecular cloning, qPCR, cell culture, ELISA, plate-based luciferase and/or enzymatic activity assays, SDS-PAGE/Western blotting, etc. is required.

• Experience with AAV gene therapy is required.

• Travel may be required, but infrequently and for short periods of time.

Preferred Qualifications:

• Experience with studies in laboratory animal models is preferred.

• Strong analytical skills and problem-solving capabilities.

• Familiar with computer software commonly used in bio/pharma industries.

• Strong publication record is a plus.

• Experience managing external collaborations is a plus.

The expected salary range for this position based on the primary location of Philadelphia is $103,400 to $192,000.Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. This position also qualifies for the benefits detailed at the link provided below.

This position also qualifies for the benefits detailed at the link provided below.

Benefits

Relocation benefits are not available for this role.

A healthier future drives us to innovate. Together, more than 100'000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let's build a healthier future, together.

Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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