Principal Imaging Scientist/ MD Radiologist

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This role is based in the Digital Endpoints and Patient-Centered Solutions (DEPCS) team, the innovative digital, AI, and tech function within Roche Product Development Data Sciences (PDD). Operating across the Science of Medicines and Operations, DEPCS is responsible for embedding patient-centered and AI-enabled digital solutions into the fabric of clinical research. By integrating data science, measurement science, and digital product thinking, DEPCS delivers scalable and regulatory-ready innovations that enhance trial design, evidence generation, and clinical value of Roche medicines.

The Opportunity:

The Imaging Scientist / MD Radiologist plays a central role in advancing imaging science within DEPCS by developing, validating, and guiding the use of imaging-based biomarkers and AI-powered solutions across drug development. With expertise in radiology and medical image interpretation, this role supports the integration of imaging into clinical trial protocols and ensures scientific, technical, and regulatory rigor in imaging applications. Collaborating with cross-functional teams-including data scientists, clinical experts, and biostatisticians-this role shapes how imaging contributes to evidence generation, patient-centric strategies, and therapeutic innovation across TAs.

• You provide clinical imaging scientific advice for study/project teams and during interactions with imaging service providers

• You contribute to imaging science strategy across disease areas and clinical programs within DEPCS TA Digital Strategy

• You develop relationships with cross-functional stakeholders to ensure proactive consideration of imaging strategies during clinical development planning

• You employ imaging expertise to answer questions and address issues that arise during ongoing clinical trials, for instance advising on criteria-, modality-, or medical questions raised by medical monitors

• You finalize imaging charters (e.g., RECIST or Lugano in oncology) and provide input on additional criteria to add value to the specific protocol

• You perform tasks related to image data management, image transfer, and organization

• You independently execute analysis of a variety of radiology imaging data (PET, CT, MRI), preferably with AI/ML tools

• You identify opportunities and support inclusion of novel automated imaging analysis biomarkers in late-stage clinical trials

• You support communications with reading centers and contribute to creation/editing of imaging manuals, imaging review charters/grading protocols, image transfer agreements, etc.

• You contribute scientific expertise for novel imaging biomarker development and validation

• You support radiologist networks and ensure consistency, quality, and scalability of annotations

• You facilitate internal education and innovation around imaging-enabled trial design and analysis

• You informally mentor junior team members by leveraging technical experience to build subject matter expertise across the team and professional experience to shape growing leaders

• You implement QA of imaging annotations and vendor deliverables in alignment with regulatory expectations

Who you are:

• You are a board certified MD with formal radiology training (residency and/or fellowship), 6+ years experience practicing radiology post-training, 2+ years of biotech/pharma/academic experience, or other relevant experience of using imaging in clinical trials OR You have a Masters of Science or Masters of Engineering degree with 6+ years of biotech/pharma/academic experience, or other relevant experience of using imaging in clinical trials OR You hold a PhD in relevant scientific/engineering discipline preferred with 4+ years of relevant biotech/pharma/academic experience, or other relevant experience of using imaging in clinical trials

• You have experience developing and/or using artificial intelligence-based radiology tools

• You bring deep expertise in imaging interpretation, imaging-based endpoints, and imaging standards

• You have experience leading imaging strategies in support of drug development or regulatory submissions

• You have experience with 'hands-on' quantitative analysis of imaging data in clinical trials (familiarity with PET, CT, MRI imaging)

• You have experience working with MATLAB or Python

• You have a good working knowledge of statistics and its applications within the biomedical sciences

• You are familiar with clinical trial regulations and Good Clinical Practice (GCP)

• You demonstrate capacity for independent thinking and ability to make decisions based upon sound principles

• You bring excellent strategic agility including problem-solving and critical thinking skills, and agility that extends beyond the technical domain

• You demonstrate respect for cultural differences when interacting with colleagues in the global workplace

• You have excellent verbal and written communication skills, specifically in the areas of presentation and writing, with the ability to explain complex technical concepts in clear language

Preferred:

• Record of publications or conference presentations related to imaging or AI in medicine

• Experience mentoring radiologists or leading imaging review networks

• Familiarity with regulatory engagement related to imaging endpoints or tools

Relocation benefits are not available for this posting

The expected salary range for this position based on the primary location of California is $233,500.00 - $433,600.00 USD Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

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Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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