Principal Scientist, Inflammation and Fibrosis

Business Introduction
At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding of the immune system with cutting-edge technology to transform people's lives. GSK fosters a culture ambitious for patients, accountable for impact, and committed to doing the right thing, making sure that we focus our efforts on accelerating significant assets that meet patients' needs and have the highest probability of success. We're uniting science, technology, and talent to get ahead of disease together.
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Our approach to R&D

Position Summary

We are seeking a highly motivated, enthusiastic and skilled cell biologist to join our group within the Human Biology department at our US Research Hub. This laboratory-based role is critical to advancing our early discovery efforts through the development and application of physiologically relevant in vitro models that mimic complex disease biology. The successful candidate will leverage cutting-edge technologies, including primary human cells, phenotypic profiling, gene editing, and functional genomics, to drive target discovery and validation efforts in areas of high unmet medical need. Working in a multidisciplinary and collaborative environment, you will generate impactful insights that inform and accelerate therapeutic discovery and development.

Responsibilities include:

This role will provide YOU the opportunity to lead key activities to progress YOUR career. These responsibilities include some of the following:

• Laboratory-based role

• Lead the design and execution of experiments involving primary human cells and advanced in vitro systems to support early target discovery, validation and mechanistic studies.

• Develop and apply complex cellular models (e.g., co-culture, 3D systems) to better recapitulate human disease biology (e.g. autoimmune, fibrosis).

• Apply CRISPR-based gene editing, molecular biology, automation, and high-dimensional flow cytometry techniques to interrogate gene function in disease contexts.

• Translate biological insights into clinically actionable therapeutic strategies, aligned with disease-relevant endpoints.

• Collaborate cross-functionally with internal and external partners in human genetics, computational biology, AI/ML, automation, and disease areas.

• Maintain excellent experimental records according to GSK compliance.

• Communicate experimental findings effectively (in written and verbal formats) in internal and external scientific forums

Basic Qualifications

We are looking for professionals with these required skills to achieve our goals:

• PhD in Immunology, Cell Biology, Bioengineering or related life sciences field

• 2+ years of research experience in a postdoctoral or industry setting

• Authorship or coauthorship on peerreviewed scientific publications.

• Three or more years of handson experience performing basic molecular and cellular techniques, such as molecular cloning, immunostaining, flow cytometry, ELISA, and cell culture.

• Handson experience working with advanced cellular models, including primary cell cultures, coculture systems, and/or 3D cell systems.

Preferred Experience

If you have the following characteristics, it would be a plus:

• Experience with multi-omics, high-dimensional flow cytometry, MSD, automated platforms, and/or high-content imaging technologies.

• Strong scientific curiosity with a drive to innovate and continuously learn

• Proven ability to work effectively in collaborative and matrixed environments

• Quick learner who is driven to deliver impact.

• Excellent communication skills, with the ability to clearly articulate complex scientific concepts

• Emerging or demonstrated scientific leadership, with the ability to influence project direction and mentor others

#LI-GSK

Our values and expectations
We look for team members who act with patient focus, transparency, respect, and integrity. You will be expected to operate at pace, use evidence to make thoughtful decisions, and deliver high quality results. We value learning, collaboration, and well-being. We welcome candidates who bring different perspectives and life experiences. If this role matches your skills and ambitions, please apply and tell us how you will contribute.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?

Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at - usrecruitment.adjustments@gsk.com

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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